Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

Somatosensory afferents are traditionally classified by soma size, myelination, and their
response specificity to external and internal stimuli. Here, we propose the functional …

In humans, gamma-band oscillations in the primary somatosensory cortex (S1) correlate
with subjective pain perception. However, functional contributions to pain and the nature of …

Acupuncture has been practiced for more than 2000 years in China and now all over the
world. One core idea behind this medical practice is that stimulation at specific body regions …

Effective management of pain is critical to the improvement of animal welfare. For this to
happen, pain must be recognised and assessed in a variety of contexts. Pain is a complex …

The primary somatosensory cortex (S1) is a hub for body sensation of both innocuous and
noxious signals, yet its role in somatosensation versus pain is debated. Despite known …

Neuropathic pain following spinal cord injury involves plastic changes along the whole
neuroaxis. Current neuroimaging studies have identified grey matter volume (GMV) and …

The habenula has been implicated in the pathogenesis of pain and analgesia, while
evidence concerning its function in chronic low back pain (cLBP) is sparse. This study aims …

Background Early exposure to nociceptive events may cause brain structural alterations in
preterm neonates, with long-lasting consequences on neurodevelopmental outcome. Little …