Purpose Although preclinical studies on camptothecin antitumor effect have demonstrated
the superiority of low-dose protracted dosing, these findings were not replicated in the clinic …

非小细胞肺癌对表皮生长因子受体-酪氨酸激酶抑制剂(EGFR-TKIs) 的耐药问题已成为研究的
热点. 最近研究发现EGFR 和COX-2 信号通路之间存在着复杂的相互联系和作用, 抑制COX-2 …

A curve-free, Bayesian decision-theoretic two-stage design is proposed to select biological
efficacious doses (BEDs) for phase Ia/Ib trials in which both toxicity and efficacy signals are …

Background: Lung cancer represents the leading cause of cancer-related deaths worldwide
and novel therapeutic approaches targeting crucial pathways are urgently needed to …

目的观察不同抗原修复方法及修复液对COX-2 抗原表达的影响及其与乳腺癌临床病理特征的
关系. 方法用光波/微波, 高压锅结合枸椽酸缓冲液, EDTA 作抗原修复处理 …

非甾体类抗炎药(NSAIDs) 作用靶点为环氧化酶, 环氧化酶是催化花生四烯酸转化为前列腺素的
限速酶. 目前已被证实至少有2 种同工酶COX-1 和COX-2. COX-2 被认为是诱导型反应基因 …

In a randomized trial, the combination of the cyclooxygenase 2 (COX‐2) inhibitor celecoxib
with erlotinib demonstrated improved progression‐free survival in patients with elevated …

One of the major causes of death in the world is cancer. Due to significant advances in
molecular and cellular biology, previous approaches in cancer treatment have progressed …

While genetic changes are critical for the malignant transformation of epithelial cells, the
microenvironment in which the cells reside also governs carcinogenesis. Most tumors arise …