One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …

Breast cancer (BC) is the most frequently occurring malignancy in women worldwide.
Despite the substantial advancement in understanding the molecular mechanisms and …

Traditional therapies against cancer, chemo-and radiotherapy, have multiple limitations that
lead to treatment failure and cancer recurrence. These limitations are related to systemic …

Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

Since last two decades, the major cancer research has focused on understanding the
characteristic properties and mechanism of formation of Cancer stem cells (CSCs), due to …

Here we investigated different cell populations within ovarian cancer using single-cell RNA
seq: fourteen samples from nine patients with differing grades (high grade, low grade and …

A hostile tumor microenvironment is one of the major obstacles for the efficacy of chimeric
antigen receptor modified T (CAR-T) cells, and combination treatment might be a potential …

The chemokine CXCL14 is a highly conserved, homeostatic chemokine that is constitutively
expressed in skin epithelia. Responsible for immune cell recruitment and maturation, as well …

The establishment of bone metastasis remains one of the most frequent complications of
patients suffering from advanced breast cancer. Patients with bone metastases experience …

Overactivation of PI3K/Akt/mTOR is linked with carcinogenesis and serves a potential
molecular therapeutic target in treatment of various cancers. Herein, we report the synthesis …