Clinical Implications of Genomic Discoveries in Lung Cancer | New England Journal of Medicine
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Simple Summary Aberrant DNA methylation is associated with multiple malignancies,
including lung cancer. Differences in methylation patterns have been observed across lung …

Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …

Advanced metastatic cancer poses utmost clinical challenges and may present molecular
and cellular features distinct from an early-stage cancer. Herein, we present single-cell …

Regulatory networks that maintain functional, differentiated cell states are often dysregulated
in tumor development. Here, we use single-cell epigenomics to profile chromatin state …

The use of potent therapies inhibiting critical oncogenic pathways active in epithelial
cancers has led to multiple resistance mechanisms, including the development of highly …

Lung adenocarcinomas (LUAD) arise from precancerous lesions such as atypical
adenomatous hyperplasia, which progress into adenocarcinoma in situ and minimally …

Introduction Pathological examination of histopathological slides is a routine clinical
procedure for lung cancer diagnosis and prognosis. Although the classification of lung …

Small cell lung cancer (SCLC) is an extremely aggressive neuroendocrine tumor,
accounting for approximated 13% of all lung cancer cases. SCLC is characterized by rapid …

The initiating oncogenic event in almost half of human lung adenocarcinomas is still
unknown, a fact that complicates the development of selective targeted therapies. Yet these …