Manipulating the destiny of wild populations using CRISPR
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
health, agriculture, and biodiversity. Advancements in genome engineering technologies …
Curing mosquitoes with genetic approaches for malaria control
Malaria remains a persistent global public health challenge because of the limitations of
current prevention tools. The use of transgenic mosquitoes incapable of transmitting malaria …
current prevention tools. The use of transgenic mosquitoes incapable of transmitting malaria …
A population modification gene drive targeting both Saglin and Lipophorin impairs Plasmodium transmission in Anopheles mosquitoes
EI Green, E Jaouen, D Klug, RP Olmo, A Gautier… - Elife, 2023 - elifesciences.org
Lipophorin is an essential, highly expressed lipid transport protein that is secreted and
circulates in insect hemolymph. We hijacked the Anopheles coluzzii Lipophorin gene to …
circulates in insect hemolymph. We hijacked the Anopheles coluzzii Lipophorin gene to …
Conceptual risk assessment of mosquito population modification gene-drive systems to control malaria transmission: preliminary hazards list workshops
A Kormos, G Dimopoulos, E Bier… - … in Bioengineering and …, 2023 - frontiersin.org
The field-testing and eventual adoption of genetically-engineered mosquitoes (GEMs) to
control vector-borne pathogen transmission will require them meeting safety criteria …
control vector-borne pathogen transmission will require them meeting safety criteria …
A homing rescue gene drive with multiplexed gRNAs reaches high frequency in cage populations but generates functional resistance
S Hou, J Chen, R Feng, X Xu, N Liang… - Journal of Genetics and …, 2024 - Elsevier
CRISPR homing gene drives have considerable potential for managing populations of
medically and agriculturally significant insects. They operate by Cas9 cleavage followed by …
medically and agriculturally significant insects. They operate by Cas9 cleavage followed by …
Y chromosome shredding in Anopheles gambiae: Insight into the cellular dynamics of a novel synthetic sex ratio distorter
Despite efforts to explore the genome of the malaria vector Anopheles gambiae, the Y
chromosome of this species remains enigmatic. The large number of repetitive and …
chromosome of this species remains enigmatic. The large number of repetitive and …
Discovering weak signals of emerging topics with a triple-dimensional framework
M Ma, J Mao, G Li - Information Processing & Management, 2024 - Elsevier
In the rapidly evolving landscape of innovation, the early identification of emerging topics is
crucial across diverse research domains. This study views weak signals as the preliminary …
crucial across diverse research domains. This study views weak signals as the preliminary …
Genetic and geographic population structure in the malaria vector, Anopheles farauti, provides a candidate system for pioneering confinable gene-drive releases
Indoor insecticide applications are the primary tool for reducing malaria transmission in the
Solomon Archipelago, a region where Anopheles farauti is the only common malaria vector …
Solomon Archipelago, a region where Anopheles farauti is the only common malaria vector …
MGDrivE 3: A decoupled vector-human framework for epidemiological simulation of mosquito genetic control tools and their surveillance
A Mondal, HM Sánchez C… - PLOS Computational …, 2024 - journals.plos.org
Novel mosquito genetic control tools, such as CRISPR-based gene drives, hold great
promise in reducing the global burden of vector-borne diseases. As these technologies …
promise in reducing the global burden of vector-borne diseases. As these technologies …
Considerations for first field trials of low-threshold gene drive for malaria vector control
JB Connolly, A Burt, G Christophides, A Diabate… - Malaria Journal, 2024 - Springer
Sustainable reductions in African malaria transmission require innovative tools for mosquito
control. One proposal involves the use of low-threshold gene drive in Anopheles vector …
control. One proposal involves the use of low-threshold gene drive in Anopheles vector …