Chemokines, which are basic proteins that exert their effects via G protein-coupled receptors
and a subset of the cytokine family, are mediators deeply involved in leukocyte migration …

Chemokines are a large family of small secreted proteins that have fundamental roles in
organ development, normal physiology, and immune responses upon binding to their …

Despite the high response rate after surgery and platinum-combination chemotherapy,
treatment of ovarian cancer remains challenging due to tumor recurrence and metastasis …

Prototypical functions of the chemokine receptor CCR6 include immune regulation by
maneuvering cell chemotaxis and selective delimiting of the pro-inflammatory TH17 and …

Rhinovirus (RV) infection of the bronchial epithelium is implicated in the vast majority of
severe asthma exacerbations. Interestingly, the susceptibility of bronchial epithelium to RV …

The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a
wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling …

This study investigated tumor-associated macrophages activity in the microenvironment of
renal cell carcinoma. Via a co-culture with macrophage-like cells differentiated from human …

Tumors exhibit a variety of strategies to dampen antitumor immune responses. With an aim
to identify factors that are secreted from tumor cells, we performed an unbiased mass …

Despite the association of prevalent health conditions with coronavirus disease 2019
(COVID-19) severity, the disease-modifying biomolecules and their pathogenetic …

The C–C motif ligand 20 (CCL20) is a chemokine that specifically binds to the chemokine
receptor 6 (CCR6) and the CCL20/CCR6 axis has been implicated in the non-small lung …