Metabolism of cancer cells is geared toward biomass production and proliferation. Since the
metabolic resources within the local tissue are finite, this can lead to nutrient depletion and …

Glutamine metabolism is reprogrammed during tumorigenesis and has been investigated as
a promising target for cancer therapy. However, efforts to drug this process are confounded …

Triple-negative breast cancer (TNBC) remains an unmet medical challenge. We investigated
metabolic dysregulation in TNBCs by using our multi-omics database (n= 465, the largest to …

Clearance of apoptotic cells by macrophages prevents excessive inflammation and supports
immune tolerance. Here, we examined the effect of blocking apoptotic cell clearance on anti …

In KRAS-mutant lung adenocarcinoma, tumors with LKB1 loss (KL) are highly enriched for
concurrent KEAP1 mutations, which activate the KEAP1/NRF2 pathway (KLK). Here, we …

Breast cancer has become a serious threat to women's health. Cancer progression is mainly
derived from resistance to apoptosis induced by procedures or therapies. Therefore, new …

In neutrophils, nicotinamide adenine dinucleotide phosphate (NADPH) generated via the
pentose phosphate pathway fuels NADPH oxidase NOX2 to produce reactive oxygen …

Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

Besides fast glucose catabolism, many types of cancers are characterized by elevated
glutamine consumption. Medical oncology pursuits to block specific pathways, mainly …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …