Abstract α-Synucleinopathies are a group of neurodegenerative disorders characterized by
alterations in α-synuclein (α-syn), a protein associated with membrane phospholipids …

The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein
protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α …

Abstract α-Synuclein is a protein that mainly exists in the presynaptic terminals. Abnormal
folding and accumulation of α-synuclein are found in several neurodegenerative diseases …

Especially in higher eukaryotes, the N termini of proteins are subject to enzymatic
modifications, with the acetylation of the alpha‐amino group of nascent polypeptides being a …

A recent study by Kumar et al. identified several biological pathways that regulate the levels
of endogenous alpha-synuclein (α-synuclein). They specifically highlighted the N-terminal …

It has been hypothesized that‐‐Parkinson's disease (PD) may be initiated in the
gastrointestinal tract, before manifesting in the central nervous system. In this respect, it was …

Parkinson's disease is associated with the aberrant aggregation of α-synuclein within brain
cells. Although the causes of this process are still unclear, post-translational modifications of …

Covalent attachment of biologically active peptides/proteins with functional moieties is an
effective strategy to control their biodistribution, pharmacokinetics, enzymatic digestion, and …

α- 突触核蛋白的异常修饰及在帕金森病中的作用机制 Page 1 Chinese Journal of Tissue
Engineering Research|Vol 28|No.8|March 2024|1301 中国组织工程研究 Chinese Journal of …

Amyloid formation by alpha-synuclein (alphaSyn) occurs in Parkinsons disease, multiple
system atrophy, and dementia with Lewy bodies. Deciphering the residues that regulate …