Aptamer-based assembly systems for SARS-CoV-2 detection and therapeutics

Y Dong, J Wang, L Chen, H Chen, S Dang… - Chemical Society …, 2024 - pubs.rsc.org
Nucleic acid aptamers are oligonucleotide chains with molecular recognition properties.
Compared with antibodies, aptamers show advantages given that they are readily produced …

SARS-CoV-2 Omicron Subvariants Do Not Differ Much in Binding Affinity to Human ACE2: A Molecular Dynamics Study

HL Nguyen, TQ Nguyen, MS Li - The Journal of Physical …, 2024 - ACS Publications
The emergence of the variant of concern Omicron (B. 1.1. 529) of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) exacerbates the COVID-19 pandemic due to its high …

Deciphering the free energy landscapes of SARS-CoV-2 wild type and Omicron variant interacting with human ACE2

PD Lan, DA Nissley, EP O'Brien, TT Nguyen… - The Journal of Chemical …, 2024 - pubs.aip.org
The binding of the receptor binding domain (RBD) of the SARS-CoV-2 spike protein to the
host cell receptor angiotensin-converting enzyme 2 (ACE2) is the first step in human viral …

Nanobody Engineering: Computational Modelling and Design for Biomedical and Therapeutic Applications

N El Salamouni, J Cater, L Spenkelink, H Yu - 2024 - chemrxiv.org
Nanobodies, the smallest functional antibody fragment derived from camelid heavy-chain-
only antibodies, have emerged as powerful tools for diverse biomedical applications. In this …