Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Bioenergetic dysfunction is emerging as a cornerstone for establishing a framework for
understanding the pathophysiology of cardiovascular disease, diabetes, cancer and …

Owing to the dominant functions of mitochondria in multiple cellular metabolisms and distinct
types of regulated cell death, maintaining a functional mitochondrial network is fundamental …

Mitochondria are very versatile organelles in continuous fusion and fission processes in
response to various cellular signals. Mitochondrial dynamics, including mitochondrial …

Coenzyme Q 10 is a remarkable lipid involved in many cellular processes such as energy
production through the mitochondrial respiratory chain (RC), beta-oxidation of fatty acids …

Diabetic cardiomyopathy is a heart muscle-specific disease that increases the risk of heart
failure and mortality in diabetic patients independent of vascular pathology. Mitochondria …

Mitochondrial permeability transition (MPT) is the sudden loss in the permeability of the
inner mitochondrial membrane (IMM) to low-molecular-weight solutes. Due to osmotic …

Coenzyme Q (CoQ) is a unique electron carrier in the mitochondrial respiratory chain, which
is synthesized on-site by a nuclear encoded multiprotein complex. CoQ receives electrons …

For a number of years, coenzyme Q10 (CoQ10) was known for its key role in mitochondrial
bioenergetics; later studies demonstrated its presence in other subcellular fractions and in …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …