Targeting mitochondrial dysfunction with small molecules in intervertebral disc aging and degeneration
M Saberi, X Zhang, A Mobasheri - Geroscience, 2021 - Springer
The prevalence of rheumatic and musculoskeletal diseases (RMDs) including osteoarthritis
(OA) and low back pain (LBP) in aging societies present significant cost burdens to health …
(OA) and low back pain (LBP) in aging societies present significant cost burdens to health …
Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement
MD Cordero, FJ Cano-García, E Alcocer-Gómez… - PloS one, 2012 - journals.plos.org
Background Fibromyalgia (FM) is a chronic pain syndrome with unknown etiology and a
wide spectrum of symptoms such as allodynia, debilitating fatigue, joint stiffness and …
wide spectrum of symptoms such as allodynia, debilitating fatigue, joint stiffness and …
Modulating mitophagy in mitochondrial disease
Mitochondrial diseases may result from mutations in the maternally-inherited mitochondrial
DNA (mtDNA) or from mutations in nuclear genes encoding mitochondrial proteins. Their bi …
DNA (mtDNA) or from mutations in nuclear genes encoding mitochondrial proteins. Their bi …
Mitophagy and DNA damage signaling in human aging
Aging is associated with multiple human pathologies. In the past few years mitochondrial
homeostasis has been well correlated with age-related disorders and longevity …
homeostasis has been well correlated with age-related disorders and longevity …
Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants
CH He, LX Xie, CM Allan, UPC Tran… - Biochimica et Biophysica …, 2014 - Elsevier
Coenzyme Q biosynthesis in yeast requires a multi-subunit Coq polypeptide complex.
Deletion of any one of the COQ genes leads to respiratory deficiency and decreased levels …
Deletion of any one of the COQ genes leads to respiratory deficiency and decreased levels …
Regulation and function of mitophagy in development and cancer
Beyond its role in recycling intracellular components nonselectively to sustain survival in
response to metabolic stresses, autophagy can also selectively degrade specific cargoes …
response to metabolic stresses, autophagy can also selectively degrade specific cargoes …
F-box protein 7 mutations promote protein aggregation in mitochondria and inhibit mitophagy
ZD Zhou, SP Xie, S Sathiyamoorthy… - Human molecular …, 2015 - academic.oup.com
The mutations of F-box protein 7 (FBXO7) gene (T22M, R378G and R498X) are associated
with a severe form of autosomal recessive juvenile-onset Parkinson's disease (PD)(PARK …
with a severe form of autosomal recessive juvenile-onset Parkinson's disease (PD)(PARK …
The endoplasmic reticulum stress response in neuroprogressive diseases: emerging pathophysiological role and translational implications
The endoplasmic reticulum (ER) is the main cellular organelle involved in protein synthesis,
assembly and secretion. Accumulating evidence shows that across several …
assembly and secretion. Accumulating evidence shows that across several …
Secondary CoQ10 deficiency, bioenergetics unbalance in disease and aging
P Navas, MV Cascajo, M Alcázar‐Fabra… - Biofactors, 2021 - Wiley Online Library
Abstract Coenzyme Q10 (CoQ10) deficiency is a rare disease characterized by a decreased
accumulation of CoQ10 in cell membranes. Considering that CoQ10 synthesis and most of …
accumulation of CoQ10 in cell membranes. Considering that CoQ10 synthesis and most of …
Clinical characteristics of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes
HC Fan, HF Lee, CT Yue, CS Chi - Life, 2021 - mdpi.com
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS)
syndrome, a maternally inherited mitochondrial disorder, is characterized by its genetic …
syndrome, a maternally inherited mitochondrial disorder, is characterized by its genetic …