Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy

NJ Byrne, NS Rajasekaran, ED Abel… - Free Radical Biology and …, 2021 - Elsevier
Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Autophagy in the diabetic heart: a potential pharmacotherapeutic target in diabetic cardiomyopathy

S Dewanjee, J Vallamkondu, RS Kalra, A John… - Ageing research …, 2021 - Elsevier
Association of diabetes with an elevated risk of cardiac failure has been clinically evident.
Diabetes potentiates diastolic and systolic cardiac failure following the myocardial infarction …

Increasing fatty acid oxidation prevents high-fat diet–induced cardiomyopathy through regulating parkin-mediated mitophagy

D Shao, SC Kolwicz Jr, P Wang, ND Roe, O Villet… - Circulation, 2020 - Am Heart Assoc
Background: Increased fatty acid oxidation (FAO) has long been considered a culprit in the
development of obesity/diabetes mellitus–induced cardiomyopathy. However, enhancing …

Inflammation and metabolic cardiomyopathy

K Nishida, K Otsu - Cardiovascular research, 2017 - academic.oup.com
Excessive feeding is associated with an increase in the incidence of chronic metabolic
diseases, such as obesity, insulin resistance, and type 2 diabetes. Metabolic disturbance …

The diabetic cardiomyopathy: the contributing pathophysiological mechanisms

T Salvatore, PC Pafundi, R Galiero, G Albanese… - Frontiers in …, 2021 - frontiersin.org
Individuals with diabetes mellitus (DM) disclose a higher incidence and a poorer prognosis
of heart failure (HF) than non-diabetic people, even in the absence of other HF risk factors …

[HTML][HTML] Sirt3 deficiency exacerbates diabetic cardiac dysfunction: role of Foxo3A-Parkin-mediated mitophagy

W Yu, B Gao, N Li, J Wang, C Qiu, G Zhang… - … et Biophysica Acta (BBA …, 2017 - Elsevier
Diabetic cardiomyopathy (DCM) is often associated with suppressed cardiac autophagy,
mitochondrial structural and functional impairment. Sirtuin-3 (Sirt3) has been reported to …

[HTML][HTML] Interplay of oxidative, nitrosative/nitrative stress, inflammation, cell death and autophagy in diabetic cardiomyopathy

ZV Varga, Z Giricz, L Liaudet, G Haskó… - … et Biophysica Acta (BBA …, 2015 - Elsevier
Diabetes is a recognized risk factor for cardiovascular diseases and heart failure. Diabetic
cardiovascular dysfunction also underscores the development of diabetic retinopathy …

Of mice and men: models and mechanisms of diabetic cardiomyopathy

C Riehle, J Bauersachs - Basic research in cardiology, 2019 - Springer
Diabetes mellitus increases the risk of heart failure independent of co-existing hypertension
and coronary artery disease. Although several molecular mechanisms for the development …

Mitophagy in diabetic cardiomyopathy: roles and mechanisms

H Zheng, H Zhu, X Liu, X Huang, A Huang… - Frontiers in Cell and …, 2021 - frontiersin.org
Cardiovascular disease is the leading complication of diabetes mellitus (DM), and diabetic
cardiomyopathy (DCM) is a major cause of mortality in diabetic patients. Multiple …

[HTML][HTML] Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: therapeutic targeting, challenges and future prospective

M Hashemi, MA Zandieh, S Ziaolhagh… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …