As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

The 3D structure and surface characteristics of proteins and peptides are crucial for
interactions with receptors or ligands and can be modified to some extent to modulate their …

Antimicrobial peptides have attracted considerable interest as potential new class of
antibiotics against multi-drug resistant bacteria. However, their therapeutic potential is …

Halogenation is widespread in Nature, as witnessed by the several thousands of naturally
occurring halogenated compounds. This review seeks to provide an overview on the …

Multidrug-resistant (MDR) bacteria are considered a health threat worldwide, and this
problem is set to increase over the decades. The ESKAPE, a group of six pathogens …

Mimics of antimicrobial peptides (AMPs) have been proposed as a promising class of
antimicrobial agents. We report the analysis of five tetrasubstituted, cationic, amphipathic …

An amphipathic barbiturate mimic of the marine eusynstyelamides is reported as a
promising class of antimicrobial agents. We hereby report a detailed analysis of the structure …

The emergence of drug-resistant strains and new pathogens intensifies the need for new
antimicrobials. Additionally, bacterial biofilms, which contribute to persistent infections …

Effective antimicrobial drugs are the very core of modern medicine enabling successful
prevention and treatment of infectious diseases. However, systemic misuse and overuse of …

(2) Date: Oct. 27, 2021 Related US Application Data (60) Provisional application No.
62/841,227, filed on Apr. 30, 2019. is provided, wherein A is a terminal N-alkyl substituted …