Emergency management of community-acquired bacterial pneumonia: what is new since the 2007 Infectious Diseases Society of America/American Thoracic Society …

GJ Moran, RE Rothman, GA Volturo - The American journal of emergency …, 2013 - Elsevier
Community-acquired pneumonia (CAP) is a major health problem in the United States and
is associated with substantial morbidity, mortality, and health care costs. Patients with CAP …

Antibiotic resistance in community-acquired pneumonia pathogens

RG Wunderink, Y Yin - Seminars in respiratory and critical care …, 2016 - thieme-connect.com
The overwhelming majority of cases of community-acquired pneumonia (CAP) can be
treated with the standard antibiotic regimens of a macrolide and cephalosporin or a …

Efficacy and effectiveness of Ceftaroline Fosamil in patients with pneumonia: a systematic review and meta-analysis

G Sotgiu, S Aliberti, A Gramegna, M Mantero… - Respiratory …, 2018 - Springer
Background Pneumonia is a relevant clinical and public health issue worldwide frequently
associated with infections caused by Multi-Drug Resistant (MDR) pathogens. Ceftaroline …

Ceftaroline fosamil in the treatment of community-acquired bacterial pneumonia and acute bacterial skin and skin structure infections

TP Lodise, DE Low - Drugs, 2012 - Springer
Ceftaroline fosamil is a cephalosporin antibacterial approved by the US Food and Drug
Administration (FDA) for use in the treatment of acute bacterial skin and skin structure …

The changing microbiologic epidemiology of community-acquired pneumonia

S Aliberti, KS Kaye - Postgraduate medicine, 2013 - Taylor & Francis
Community-acquired pneumonia (CAP) is a common infectious disease in the United States
and the incidence continues to grow as the aging population increases. Overall, in-hospital …

Neutropenia associated with long-term ceftaroline use

KW LaVie, SW Anderson, HR O'Neal Jr… - Antimicrobial Agents …, 2016 - Am Soc Microbiol
Ceftaroline is a fifth-generation cephalosporin with potent antimicrobial activity against Gram-
positive and Gram-negative pathogens. Neutropenia is a rare serious adverse event for the …

The Inherited Intestinal Microbiota from Myeloid-Specific ZIP8KO Mice Impairs Pulmonary Host Defense against Pneumococcal Pneumonia

DR Samuelson, DR Smith, KC Cunningham, S Haq… - Pathogens, 2023 - mdpi.com
Intestinal dysbiosis increases susceptibility to infection through the alteration of metabolic
profiles, which increases morbidity. Zinc (Zn) homeostasis in mammals is tightly regulated by …

A series of pharmacokinetic studies of ceftaroline fosamil in select populations: normal subjects, healthy elderly subjects, and subjects with renal impairment or end …

T Riccobene, A Jakate, D Rank - The Journal of Clinical …, 2014 - Wiley Online Library
Ceftaroline fosamil is a parenteral cephalosporin indicated for the treatment of acute
bacterial skin and skin structure infections and community‐acquired bacterial pneumonia …

Ceftaroline as salvage monotherapy for persistent MRSA bacteremia

YJ Burnett, K Echevarria… - Annals of …, 2016 - journals.sagepub.com
Objective: To summarize published data regarding the use of ceftaroline as salvage
monotherapy for persistent methicillin-resistant Staphylococcus aureus (MRSA) bacteremia …

Integrated safety summary of FOCUS 1 and FOCUS 2 trials: phase III randomized, double-blind studies evaluating ceftaroline fosamil for the treatment of patients with …

DR Rank, HD Friedland… - Journal of antimicrobial …, 2011 - academic.oup.com
Objectives Ceftaroline fosamil, the prodrug of the active metabolite ceftaroline, is a broad-
spectrum, parenteral cephalosporin approved for treatment of moderate to severe bacterial …