Patients treated with conventional cancer chemotherapy suffer from side effects of the drugs
due to non-selective action of chemotherapeutic drugs to normal cells. Active targeting …

Nucleolin or C23, is one of the most abundant non-ribosomal phosphoproteins of nucleolus.
However, in several cancers, nucleolin is highly expressed both intracellularly and on the …

Using nanoparticles to carry and delivery anticancer drugs holds much promise in cancer
therapy, but nanoparticles per se are lacking specificity. Active targeting, that is, using …

Systematic evolution of ligand by exponential enrichment (SELEX) is an efficient method
used to isolate high-affinity single stranded oligonucleotides from a large random sequence …

The major issue associated with chemotherapeutics is the non-specific distribution,
extended range of toxicity, and low intratumoral accumulation. Targeted therapy using …

Over the past two decades, polymersomes have been widely investigated for the delivery of
diagnostic and therapeutic agents in cancer therapy. Polymersomes are stable polymeric …

Targeted therapy is highly desirable, as it allows for selective cytotoxicity on diseased cells
without off-target side effects. Nucleolin is a remarkable target for cancer therapy given its …

Gold NPs have great potential in biomedical applications. PAMAM dendrimers are spherical,
hyper branched macromolecules which can encapsulate therapeutic molecules while …

Based on exceptional advantages of aptamers, increasing attention has been presented in
the utilise of them as targeted ligands for cancer drug delivery. Recently, the progress of …

Diverse nanosystems for use in cancer imaging and therapy have been designed and their
clinical applications have been assessed. Among a variety of materials available to fabricate …