We summarize recent advances in application of MOFs as therapeutic agents, drug carriers,
imaging agents and biosensors in cancer biomedicine. A holistic perspective is adopted to …

The concept of a scaffold concerns many aspects at different steps on the drug development
path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point …

Cancer is a serious threat to human beings and is the second-largest cause of death all over
the globe. Chemotherapy is one of the most common treatments for cancer; however, drug …

AIM: To investigate the function of microRNA-143 (miR-143) in gastric cancer and explore
the target genes of miR-143. METHODS: A quantitative real-time reverse transcription …

Sulfonamides revolutionized the treatment and management of bacterial infections. Prontosil
was the very first synthetic antibacterial agent ever used in the clinics and its metabolite …

Novel silver (I) metallo-drugs of the nonsteroidal anti-inflammatory drug nimesulide (nim)
and the mitochondriotropic triaryl derivatives of pnictogen ligands (tpE, E= P (tpp, tptp, or …

Herein, fifteen new compounds containing coumarin, 1, 2, 3-triazole and benzoyl-substituted
arylamine moieties were designed, synthesized and tested in vitro for their anticancer …

Nimesulide is a nonsteroidal anti-inflammatory drug and a COX-2 inhibitor with antitumor
and antiproliferative activities that induces apoptosis in oral, esophagus, breast, and …

Nimesulide is a nonsteroidal anti-inflammatory drug possessing analgesic and antipyretic
properties. This drug is considered a selective cyclooxygenase-2 (COX-2) inhibitor and …

Two series of chiral novel compounds were designed and synthesized using a one-pot
double Mannich-type reaction, with pyrimidine, purine, and purine bioisosteres as a central …