Natural-derived alkaloids exhibit great potential in the treatment of ulcerative colitis

C Li, J Wang, R Ma, L Li, W Wu, D Cai, Q Lu - Pharmacological Research, 2022 - Elsevier
Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease of colon and rectum
with unknown etiology, and the lesions are mainly confined to the mucosa and submucosa …

[HTML][HTML] Major indole alkaloids in Evodia Rutaecarpa: the latest insights and review of their impact on gastrointestinal diseases

L Chen, Y Hu, Z Ye, L Li, H Qian, M Wu, K Qin… - Biomedicine & …, 2023 - Elsevier
Evodia rutaecarpa, the near-ripe fruit of Euodia rutaecarpa (Juss.) Benth, Euodia rutaecarpa
(Juss.) Benth. var. officinalis (Dode) Huang, or Euodia rutaecarpa (Juss.) Benth. var …

Irbesartan reprofiling for the amelioration of ethanol-induced gastric mucosal injury in rats: Role of inflammation, apoptosis, and autophagy

HH Arab, AH Eid, AAK El-Sheikh, ESA Arafa… - Life Sciences, 2022 - Elsevier
Background Pronounced anti-inflammatory and anti-apoptotic features have been
characterized for the angiotensin receptor blocker irbesartan. Yet, its effect on ethanol …

Sinapic acid attenuates chronic DSS-induced intestinal fibrosis in C57bl/6J mice by modulating NLRP3 inflammasome activation and the autophagy pathway

WY Li, JY Liu, ZX Wang, KY Wang, CX Huang, W He… - ACS …, 2023 - ACS Publications
Ulcerative colitis (UC) is a chronic gastrointestinal disease that results from repeated
inflammation and serious complications. Sinapic acid (SA) is a hydroxycinnamic acid …

Integrating network pharmacology deciphers the action mechanism of Zuojin capsule in suppressing colorectal cancer

J Fan, M Xu, L Zhou, Z Gui, L Huang, X Li, X Ye - Phytomedicine, 2022 - Elsevier
Background and purpose Zuojin capsule (ZJC), a classical prescription, is outstanding in
improving the conditions of patients with gastrointestinal diseases and colorectal cancer …

Medicinal plants, phytochemicals and regulation of the NLRP3 inflammasome in inflammatory bowel diseases: A comprehensive review

R Direito, SM Barbalho, ME Figueira, G Minniti… - Metabolites, 2023 - mdpi.com
Ongoing research explores the underlying causes of ulcerative colitis and Crohn's disease.
Many experts suggest that dysbiosis in the gut microbiota and genetic, immunological, and …

Inflammasome regulation: therapeutic potential for inflammatory bowel disease

Q Xu, X Zhou, W Strober, L Mao - Molecules, 2021 - mdpi.com
Inflammasomes are multiprotein complexes formed to regulate the maturation of pro-
inflammatory caspases, in response to intracellular or extracellular stimulants. Accumulating …

Research trends in ulcerative colitis: a bibliometric and visualized study from 2011 to 2021

T Zhang, B Zhang, W Tian, F Wang, J Zhang… - Frontiers in …, 2022 - frontiersin.org
Background: Ulcerative colitis (UC) is an idiopathic inflammatory bowel disease with
repeated relapses and remissions. Despite decades of effort, numerous aspects, including …

Intestinal macrophage autophagy and its pharmacological application in inflammatory bowel disease

Y Zheng, Y Yu, XF Chen, SL Yang, XL Tang… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD), comprised of Crohn's disease (CD) and ulcerative colitis
(UC), is a group of chronic inflammatory disorders. IBD is regarded as a severe healthcare …

[HTML][HTML] Therapeutic interventions target the NLRP3 inflammasome in ulcerative colitis: Comprehensive study

FEM Ali, IM Ibrahim, OM Ghogar… - World Journal of …, 2023 - ncbi.nlm.nih.gov
One of the significant health issues in the world is the prevalence of ulcerative colitis (UC).
UC is a chronic disorder that mainly affects the colon, beginning with the rectum, and can …