Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that
have been implicated in various pathological processes, such as inflammation and cancer …

It is widely accepted that alterations to cyclooxygenase-2 (COX-2) expression and the
abundance of its enzymatic product prostaglandin E 2 (PGE 2) have key roles in influencing …

It is now more than 15 years since the molecular structures of the major prostanoid receptors
were elucidated. Since then, substantial progress has been achieved with respect to …

Inflammation in the tumor microenvironment is now recognized as one of the hallmarks of
cancer. Endogenously produced lipid autacoids, locally acting small molecule lipid …

The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It
belongs to the family of G protein–coupled receptors. It was originally identified, similar to …

The cyclooxygenase-2 (COX-2) enzyme is frequently overexpressed in epithelial
malignancies including those of the breast, prostate, lung, kidney, ovary, and liver and …

Highlights•PGE2 receptor subtypes EP1–4 are valuable drug targets.•Structural features for
subtype-selective activity of EP1–4 receptor modulators are presented.•Binding affinities …

Elevated expression of COX‐2 and increased levels of PGE2 are found in numerous
cancers and are associated with tumour development and progression. Although …

Genetically engineered mice are essential tools in both mechanistic studies and drug
development in colon cancer research. Mice with mutations in the Apc gene, as well as in …

The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by
signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse …