Notwithstanding ceaseless endeavors toward developing effective antibiofilm
chemotherapeutics, biofilm-associated infections continue to be one of the most perplexing …

Tularemia is a zoonosis caused by the Gram negative, facultative intracellular bacterium
Francisella tularensis. This disease has multiple clinical presentations according to the route …

Tularemia, caused by Francisella tularensis, is endemic to the northern hemisphere. This
zoonotic organism has historically been developed into a biological weapon. For this Tier 1 …

Biofilms are a matrix-associated lifestyle of microbial communities, often enabling
survivability and persistence of such bacteria. The objective of this study was to investigate …

Biofilms have been established as an important lifestyle for bacteria in nature as these
structured communities often enable survivability and persistence in a multitude of …

The macrolides-resistant Bordetella pertussis (MR-Bp) isolates in China evolved from the
ptxP1/fhaB3 allele and rapidly became predominant, suggestive of an adaptive transmission …

Combination antimicrobial therapy has been considered a promising strategy to combat the
evolution of antimicrobial resistance. Francisella tularensis is the causative agent of …

Peptidoglycan, found within the cell wall of bacteria, is a structure critical for maintaining cell
morphology and providing a protective barrier in diverse environments. Peptidoglycan is a …

In vitro experimental evolution has complemented clinical studies as an excellent tool to
identify genetic changes responsible for the de novo evolution of antimicrobial resistance …

Francisella tularensis is a highly infectious Gram-negative bacterial pathogen capable of
animal-to-human transmission. Due to its remarkable pathogenicity and potential for …