Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that
regulate a wide variety of physiological responses and pathological processes. They are …

Blood vessel formation is a fundamental process for the development of organism and tissue
regeneration. Of importance, angiogenesis occurring during postnatal development is …

Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing
cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the …

HPV-DNA integration into cellular chromatin is usually a necessary event in the
pathogenesis of HPV-related cancer; however, the mechanism of integration has not been …

Lung cancer is among the most common cancers with a high mortality rate worldwide.
Despite the significant advances in diagnostic and therapeutic approaches, lung cancer …

Preclinical and clinical studies have sought to better understand the effect of anesthetic
agents, both volatile and intravenous, and perioperative adjuvant medications on immune …

Celecoxib is a paradigmatic selective inhibitor of cyclooxygenase-2 (COX-2). This anti-
inflammatory drug has potent anti-tumor activity in a wide variety of human epithelial tumor …

Wnt proteins are a large family of secreted glycoproteins. Wnt proteins bind to the Frizzled
receptors and LRP5/6 co-receptors, and through stabilizing the critical mediator β-catenin …

Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …

For centuries, nonsteroidal anti-inflammatory drugs (NSAIDs) have been part of our clinical
practice. They started out as drugs with anti-inflammatory and analgesic action, and …