Salivary gland hypofunction (SGH) caused by systemic disease, drugs, aging, and
radiotherapy for head and neck cancer can cause dry mouth, which increases the risk of …

The incidence of autoimmune diseases has significantly increased over the past 20 years.
Excessive host immunoreactions and disordered immunoregulation are at the core of the …

Autoimmune diseases commonly affect various systems, but their etiology and pathogenesis
remain unclear. Currently, increasing research has highlighted the role of ferroptosis in …

Sjögren's syndrome is a common chronic autoimmune disease that manifests as dry mouth,
dry eyes and systemic complications. There are sex differences in the clinical manifestations …

Interleukin (IL)-23 is a central pro-inflammatory cytokine with a broad range of effects on
immune responses. IL-23 is pathologically linked to the induction of the production of the pro …

Autoimmune diseases (AID) have emerged as prominent contributors to disability and
mortality worldwide, characterized by intricate pathogenic mechanisms involving genetic …

The literature is filled with citations reporting an increased incidence of chronic dry eye
disease, also known as keratoconjunctivitis sicca, in patients with systemic autoimmune …

Background Sjögren's syndrome (SS) is a chronic autoimmune disease that predominantly
affects exocrine glands. Previous studies have demonstrated that upregulated interferon …

In primary Sjögren's syndrome (pSS) patients, salivary gland (SG) epithelial cells (SGECs)
could be exposed to chronic hyperosmotic stress (HOS), consecutive to their destruction and …

Primary Sjögren's Syndrome (pSS) is a systemic autoimmune disease that leads to reduced
saliva production, primarily affecting women due to estrogen deficiency. The estrogen …