Overview of tumor cell chemoresistance mechanisms
L Gatti, F Zunino - Chemosensitivity: Volume II: In VIVO Models, Imaging …, 2005 - Springer
Drug resistance of tumor cells is recognized as the primary cause of failure of
chemotherapeutic treatment of most human tumors. Although pharmacological factors …
chemotherapeutic treatment of most human tumors. Although pharmacological factors …
Discovery and development of antimitotic agents that inhibit tubulin polymerisation for the treatment of cancer
Q Li, HL Sham - Expert Opinion on Therapeutic Patents, 2002 - Taylor & Francis
Antimitotic agents have generated considerable interest among cytotoxic agents due to the
tremendous success of the taxanes and the widespread use of the Vinca alkaloids in clinical …
tremendous success of the taxanes and the widespread use of the Vinca alkaloids in clinical …
Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian …
LYW Bourguignon, K Peyrollier, W Xia… - Journal of Biological …, 2008 - ASBMB
Hyaluronan (HA) is a major glycosaminoglycan in the extracellular matrix whose expression
is tightly linked to multidrug resistance and tumor progression. In this study we investigated …
is tightly linked to multidrug resistance and tumor progression. In this study we investigated …
Microtubule-associated parameters as predictive markers of docetaxel activity in advanced breast cancer patients: results of a pilot study
C Bernard-Marty, I Treilleux, C Dumontet, F Cardoso… - Clinical breast …, 2002 - Elsevier
Docetaxel is currently one of the most active agents for breast cancer. Predictive markers of
docetaxel efficacy are clearly needed in order to avoid unnecessary toxicity in …
docetaxel efficacy are clearly needed in order to avoid unnecessary toxicity in …
Molecular mechanisms of resistance to taxanes and therapeutic implications
F Zunino, G Cassinelli, D Polizzi, P Perego - Drug Resistance Updates, 1999 - Elsevier
The mechanism of resistance to taxanes has not been fully elucidated. Since Taxol is a
substrate for P-glycoprotein, overexpression of this transport system is recognized as a …
substrate for P-glycoprotein, overexpression of this transport system is recognized as a …
Cellular sensitivity determinants to docetaxel in human gastrointestinal cancers
JS Park, W Yamamoto, T Sekikawa… - International …, 2002 - spandidos-publications.com
Abstract β-tubulin (β-TUB), Bcl-XL, and additionally glutathione S-transferase π (GSTπ) were
found to participate in sensitivity to docetaxel (TXT) in 7 human gastrointestinal cancer cell …
found to participate in sensitivity to docetaxel (TXT) in 7 human gastrointestinal cancer cell …
Novel combination chemotherapy in the treatment of non-small cell lung cancer
I Sekine, N Saijo - Expert Opinion on Pharmacotherapy, 2000 - Taylor & Francis
Treatment of patients with advanced non-small cell lung cancer (NSCLC) remains a vexing
problem and long-term survival beyond 5 years is extremely rare. Five new agents …
problem and long-term survival beyond 5 years is extremely rare. Five new agents …
Enhancement of in vivo Antitumor Activity of a Novel Antimitotic 1‐Phenylpropenone Derivative, AM‐132, by Tumor Necrosis Factor‐cc or Interleukin‐6
Y Tatsumi, H Arioka, S Ikeda… - Japanese journal of …, 2001 - Wiley Online Library
TK5048 and its derivatives, AM‐132, AM‐138, and AM‐97, are recently developed
antimitotic (AM) compounds. These 1‐phenylpropenone derivatives induce cell cycle arrest …
antimitotic (AM) compounds. These 1‐phenylpropenone derivatives induce cell cycle arrest …