[HTML][HTML] Chain release mechanisms in polyketide and non-ribosomal peptide biosynthesis

RF Little, C Hertweck - Natural Product Reports, 2022 - pubs.rsc.org
Review covering up to mid-2021 The structure of polyketide and non-ribosomal peptide
natural products is strongly influenced by how they are released from their biosynthetic …

[HTML][HTML] The architectures of iterative type I PKS and FAS

DA Herbst, CA Townsend, T Maier - Natural product reports, 2018 - pubs.rsc.org
Covering: up to mid of 2018 Type I fatty acid synthases (FASs) are giant multienzymes
catalyzing all steps of the biosynthesis of fatty acids from acetyl-and malonyl-CoA by iterative …

Genomes to natural products prediction informatics for secondary metabolomes (PRISM)

MA Skinnider, CA Dejong, PN Rees… - Nucleic acids …, 2015 - academic.oup.com
Microbial natural products are an invaluable source of evolved bioactive small molecules
and pharmaceutical agents. Next-generation and metagenomic sequencing indicates …

Monascus secondary metabolites: production and biological activity

P Patakova - Journal of Industrial Microbiology and …, 2013 - academic.oup.com
The genus Monascus, comprising nine species, can reproduce either vegetatively with
filaments and conidia or sexually by the formation of ascospores. The most well-known …

Navigating the fungal polyketide chemical space: from genes to molecules

YH Chooi, Y Tang - The Journal of organic chemistry, 2012 - ACS Publications
The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …

New insights into the formation of fungal aromatic polyketides

JM Crawford, CA Townsend - Nature Reviews Microbiology, 2010 - nature.com
Fungal aromatic polyketides constitute a large family of bioactive natural products and are
synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their …

Biosynthesis of fusarubins accounts for pigmentation of Fusarium fujikuroi perithecia

L Studt, P Wiemann, K Kleigrewe… - Applied and …, 2012 - Am Soc Microbiol
Fusarium fujikuroi produces a variety of secondary metabolites, of which polyketides form
the most diverse group. Among these are the highly pigmented naphthoquinones, which …

[HTML][HTML] Structural enzymology of iterative type I polyketide synthases: various routes to catalytic programming

J Wang, Z Deng, J Liang, Z Wang - Natural Product Reports, 2023 - pubs.rsc.org
Time span of literature covered: up to mid-2023 Iterative type I polyketide synthases (iPKSs)
are outstanding natural chemists: megaenzymes that repeatedly utilize their catalytic …

Illuminating the Diversity of Aromatic Polyketide Synthases in Aspergillus nidulans

M Ahuja, YM Chiang, SL Chang… - Journal of the …, 2012 - ACS Publications
Genome sequencing has revealed that fungi have the ability to synthesize many more
natural products (NPs) than are currently known, but methods for obtaining suitable …

Recent advances in the identification of biosynthetic genes and gene clusters of the polyketide-derived pathways for anthraquinone biosynthesis and biotechnological …

NK Mund, E Čellárová - Biotechnology Advances, 2023 - Elsevier
Natural anthraquinones are represented by a large group of compounds. Some of them are
widespread across the kingdoms, especially in bacteria, fungi and plants, while the others …