The mammalian respiratory system—the trachea and the lungs—arises from the anterior
foregut through a sequence of morphogenetic events involving reciprocal endodermal …

During the development of the pulmonary vasculature in the fetus, many structural and
functional changes occur to prepare the lung for the transition to air breathing. The …

Pulmonary alveolar type I (AT1) cells cover more than 95% of alveolar surface and are
essential for the air–blood barrier function of lungs. AT1 cells have been shown to retain …

Alveologenesis is the culmination of lung development and involves the correct temporal
and spatial signals to generate the delicate gas exchange interface required for respiration …

Lung organogenesis requires precise timing and coordination to effect spatial organization
and function of the parenchymal cells. To provide a systematic broad-based view of the …

Bronchopulmonary dysplasia and emphysema are significant global health problems at the
extreme stages of life. Both are characterized by arrested alveolar development or loss of …

During early respiratory system development, the foregut endoderm gives rise to the
tracheal and lung cell progenitors. Through branching morphogenesis, and in coordination …

Neonatal chronic lung disease, also known as bronchopulmonary dysplasia (BPD), is the
most common complication of premature birth, affecting up to 30% of very low birth weight …

Preterm birth affects approximately 1 out of every 10 births in the United States, leading to
high rates of mortality and long-term negative health consequences. To investigate the …

The composition and mechanical properties of the extracellular matrix are dramatically
altered during the development and progression of pulmonary fibrosis. Recent evidence …