Interest in cancer metabolism has increased in recent years. The pentose phosphate
pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its …

In the field of cancer research, scientific investigations are based on analysing differences in
the secretome, the proteome, the transcriptome, the expression of cell surface molecules …

Each year, millions of pulmonary nodules are discovered by computed tomography and
subsequently biopsied. Because most of these nodules are benign, many patients undergo …

Hepatocellular carcinoma (HCC) is among the most common malignant cancers worldwide,
with an increasing incidence associated with an increase in deaths due to liver cancer. HCC …

Transketolase (TKT) is an enzyme that is ubiquitously expressed in all living organisms and
has been identified as an important regulator of cancer. Recent studies have shown that the …

Metformin has been used as first-line treatment in patients with type 2 diabetes, and is
reported to reduce cancer risk and progression by activating the liver kinase B1 (LKB1) …

Thiamine acts as a coenzyme for transketolase (Tk) and for the pyruvate dehydrogenase
and α-ketoglutarate dehydrogenase complexes, enzymes which play a fundamental role for …

Ovarian cancer, the most lethal gynaecological cancer, is characterised by the shedding of
epithelial cells from the ovarian surface, followed by metastasis and implantation onto the …

Metabolic alterations underlying clear cell renal cell carcinoma (ccRCC) progression include
aerobic glycolysis, increased pentose phosphate pathway activity and reduced oxidative …

Metastatic renal cell carcinoma (RCC) is one of the most treatment-resistant malignancies,
and patients have a dismal prognosis, with a< 10% five-year survival rate. The identification …