Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFR WT and EGFR T790M
A new series of pyrimidine-5-carbonitrile derivatives has been designed as ATP mimicking
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
tyrosine kinase inhibitors of the epidermal growth factor receptor (EGFR). These compounds …
Synthesis and antitumor activity of new dihydropyridine thioglycosides and their corresponding dehydrogenated forms
HAS Abbas, WA El Sayed, NM Fathy - European journal of medicinal …, 2010 - Elsevier
A number of a new pyridine thioglycosides were synthesized via reaction of piperidinium
salts of dihydropyridinethiones with 2, 3, 4, 6-tetra-O-acetyl-α-d-gluco-and galactopyranosyl …
salts of dihydropyridinethiones with 2, 3, 4, 6-tetra-O-acetyl-α-d-gluco-and galactopyranosyl …
[HTML][HTML] Synthesis, anticancer assessment, and molecular docking of novel chalcone-thienopyrimidine derivatives in HepG2 and MCF-7 cell lines
GM Safwat, KMA Hassanin… - … medicine and cellular …, 2021 - ncbi.nlm.nih.gov
Heterocycles containing thienopyrimidine moieties have attracted attention due to their
interesting biological and pharmacological activities. In this research article, we reported the …
interesting biological and pharmacological activities. In this research article, we reported the …
Synthesis and anticancer effects of some novel pyrazolo [3, 4-d] pyrimidine derivatives by generating reactive oxygen species in human breast adenocarcinoma cells
AE Rashad, AE Mahmoud, MM Ali - European journal of medicinal …, 2011 - Elsevier
A series of novel substituted pyrazolo [3, 4-d] pyrimidines (compounds 2–12) were
synthesized starting with pyrimidinone derivative 1. Their in vitro cytotoxicity against human …
synthesized starting with pyrimidinone derivative 1. Their in vitro cytotoxicity against human …
Synthesis and antiviral activity of 1, 2, 3-triazole glycosides based substituted pyridine via click cycloaddition
WA El-Sayed, HS Khalaf, SF Mohamed… - Russian Journal of …, 2017 - Springer
Novel conjugates of substituted pyridine and carbohydrate moieties linked by 1, 2, 3-
triazoles were synthesized. The propargyl group was introduced by O-propargylation of …
triazoles were synthesized. The propargyl group was introduced by O-propargylation of …
In vitro antioxidant and anti-inflammatory activities of Radix Isatidis extract and bioaccessibility of six bioactive compounds after simulated gastro-intestinal digestion
P Xiao, H Huang, J Chen, X Li - Journal of ethnopharmacology, 2014 - Elsevier
Abstract Ethnopharmacological relevance Radix Isatidis called “Ban-Lan-Gen” is one of the
most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory …
most commonly-used traditional Chinese medicines for antiviral, anti-inflammatory …
L-Amino acid oxidase from Cerastes vipera snake venom: Isolation, characterization and biological effects on bacteria and tumor cell lines
WH Salama, NM Ibrahim, AE El Hakim, RI Bassuiny… - Toxicon, 2018 - Elsevier
A homodimeric l-amino acid oxidase enzyme (Cv-LAAOI) was isolated from the venom of
Cerastes vipera (Egyptian Sand viper) using gel filtration followed by anion exchange …
Cerastes vipera (Egyptian Sand viper) using gel filtration followed by anion exchange …
Synthesis of new quinoline derivatives as inhibitors of human tumor cells growth
AE Rashad, WA El‐Sayed, AM Mohamed… - Archiv der …, 2010 - Wiley Online Library
Abstract A series of new 8‐[(2H‐tetrazol‐5‐yl) methoxy] quinoline derivatives, their sugar
hydrazones, and their N‐glycoside derivatives were synthesized. Furthermore, the 1, 2, 4 …
hydrazones, and their N‐glycoside derivatives were synthesized. Furthermore, the 1, 2, 4 …
New syntheses of thiosaccharides utilizing substitution reactions
R Bielski, D Mencer - Carbohydrate Research, 2023 - Elsevier
Novel synthetic methods published since 2005 affording carbohydrates containing sulfur
atom (s) are reviewed. The review is divided to subchapters based on the position of sulfur …
atom (s) are reviewed. The review is divided to subchapters based on the position of sulfur …
Synthesis and antitumor activity of new 1,2,4‐triazine and [1,2,4]triazolo[4,3‐b][1,2,4]triazine derivatives and their thioglycoside and acyclic C‐nucleoside analogs
WA El‐Sayed, IF Nassar… - Journal of Heterocyclic …, 2011 - Wiley Online Library
Abstract New 1, 2, 4‐triazine and their derived 1, 2, 4‐triazolo [3, 4‐b][1, 2, 4] triazine
derivatives were synthesized starting from 5, 6‐diphenyl‐1, 2, 4‐triazine‐3‐thiol …
derivatives were synthesized starting from 5, 6‐diphenyl‐1, 2, 4‐triazine‐3‐thiol …