Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Satellite DNA consists of abundant tandem repeats that play important roles in cellular
processes, including chromosome segregation, genome organization and chromosome end …

This article reviews the development of the immune response through neonatal, infant and
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …

Oxidative stress in skin plays a major role in the aging process. This is true for intrinsic aging
and even more for extrinsic aging. Although the results are quite different in dermis and …

Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

The long-term consequences of exposure to excess stress, particularly during sensitive
developmental windows, on the initiation and progression of many complex, common …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human
studies of telomere attrition were predominantly conducted on leukocytes. However, findings …

The attrition of telomeres, the ends of eukaryote chromosomes, is thought to play an
important role in cell deterioration with advancing age. The observed variation in telomere …

Early adversity, in the form of abuse, neglect, socioeconomic status and other adverse
experiences, is associated with poor physical and mental health outcomes. To understand …