After several decades of intensive efforts, safe injectable preparations capable of effectively
delivering O2 to tissues and removing CO2, ie, so-called blood substitutes, appear to be …

Red cells are the oxygen-carrying components of blood. In modern medical practice,
transfusions are given as suspensions of type-matched red cells in saline to replace lost …

Initial crystallographic studies suggested that fully liganded mammalian hemoglobin can
adopt only a single quaternary structure, the quaternary R structure. However, more recent …

Due to limitations associated with whole blood for transfusions (antigen compatibility,
transmission of infections, supply and storage), the use of cell-free hemoglobin as an …

A previously undefined transcript with significant homology to the pseudo-α2 region of the α-
globin locus on human chromosome 16 was detected as part of an effort to better define the …

Despite a large amount of work over the past 30 years, there is still no universal agreement
on the differential reactivities of the individual α and β subunits in human hemoglobin. To …

A detailed description of hemoglobin cooperativity requires knowledge of the dimer− dimer
interactions responsible for the low ligand affinity of the quaternary-T tetramer, the …

Many cell-free hemoglobin solutions designed as oxygen-carrying therapeutics produce a
hypertensive effect in animals. The response is likely due to oxidation of nitric oxide by …

After over a century of extensive research, hemoglobin has become the prototype of
allosteric and cooperative proteins. Its molecular structure, known in great detail, has …

The crystal structure of human deoxy hemoglobin (Hb) complexed with a potent allosteric
effector (2‐[4‐[[(3, 5‐dimethylanilino) carbonyl] methyl] phenoxy]‐2‐methylpropionic acid) …