[HTML][HTML] The JAK-STAT pathway at 30: Much learned, much more to do
The discovery of the Janus kinase (JAK)-signal transducer and activator of transcription
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
(STAT) pathway arose from investigations of how cells respond to interferons (IFNs) …
Emerging principles of cytokine pharmacology and therapeutics
Cytokines are secreted signalling proteins that play essential roles in the initiation,
maintenance and resolution of immune responses. Although the unique ability of cytokines …
maintenance and resolution of immune responses. Although the unique ability of cytokines …
Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders
R Roskoski Jr - Pharmacological Research, 2022 - Elsevier
The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1,
JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK …
JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK …
[HTML][HTML] Deucravacitinib is an allosteric TYK2 protein kinase inhibitor FDA-approved for the treatment of psoriasis
R Roskoski Jr - Pharmacological research, 2023 - Elsevier
Psoriasis is a heterogeneous, inflammatory, autoimmune skin disease that affects up to 2%
of the world's population. There are many treatment modalities including topical medicines …
of the world's population. There are many treatment modalities including topical medicines …
[HTML][HTML] Structural insights into the mechanism of leptin receptor activation
Leptin is an adipocyte-derived protein hormone that promotes satiety and energy
homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of …
homeostasis by activating the leptin receptor (LepR)–STAT3 signaling axis in a subset of …
[HTML][HTML] Jak2V617F Reversible Activation Shows Its Essential Requirement in Myeloproliferative Neoplasms
Gain-of-function mutations activating JAK/STAT signaling are seen in the majority of patients
with myeloproliferative neoplasms (MPN), most commonly JAK2 V617F. Although clinically …
with myeloproliferative neoplasms (MPN), most commonly JAK2 V617F. Although clinically …
[HTML][HTML] Recent advances in the knowledge of the mechanisms of leptin physiology and actions in neurological and metabolic pathologies
ME Casado, R Collado-Pérez, LM Frago… - International Journal of …, 2023 - mdpi.com
Excess body weight is frequently associated with low-grade inflammation. Evidence
indicates a relationship between obesity and cancer, as well as with other diseases, such as …
indicates a relationship between obesity and cancer, as well as with other diseases, such as …
[HTML][HTML] Structural basis of Janus kinase trans-activation
Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors.
Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK …
Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK …
Structural insights into the assembly of gp130 family cytokine signaling complexes
The interleukin-6 (IL-6) family cytokines signal through gp130 receptor homodimerization or
heterodimerization with a second signaling receptor and play crucial roles in various cellular …
heterodimerization with a second signaling receptor and play crucial roles in various cellular …
Biology and therapeutic targeting of molecular mechanisms in MPNs
J How, JS Garcia, A Mullally - Blood, 2023 - ashpublications.org
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders
characterized by activated Janus kinase (JAK)–signal transducer and activator of …
characterized by activated Janus kinase (JAK)–signal transducer and activator of …