[HTML][HTML] Cellular mitophagy: mechanism, roles in diseases and small molecule pharmacological regulation

Y Lu, Z Li, S Zhang, T Zhang, Y Liu, L Zhang - Theranostics, 2023 - ncbi.nlm.nih.gov
Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria
through an autophagy mechanism, thus maintaining mitochondria and intracellular …

[HTML][HTML] Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

P Jin, J Jiang, L Zhou, Z Huang, EC Nice… - Journal of Hematology & …, 2022 - Springer
Drug resistance represents a major obstacle in cancer management, and the mechanisms
underlying stress adaptation of cancer cells in response to therapy-induced hostile …

In response to precision medicine: Current subcellular targeting strategies for cancer therapy

Z Li, J Zou, X Chen - Advanced Materials, 2023 - Wiley Online Library
Emerging as a potent anticancer treatment, subcellular targeted cancer therapy has drawn
increasing attention, bringing great opportunities for clinical application. Here, two targeting …

Cuproptosis: Harnessing transition metal for cancer therapy

W Wang, W Mo, Z Hang, Y Huang, H Yi, Z Sun, A Lei - ACS nano, 2023 - ACS Publications
Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

The dawn of a new era: targeting the “undruggables” with antibody-based therapeutics

L Qian, X Lin, X Gao, RU Khan, JY Liao, S Du… - Chemical …, 2023 - ACS Publications
The high selectivity and affinity of antibodies toward their antigens have made them a highly
valuable tool in disease therapy, diagnosis, and basic research. A plethora of chemical and …

Mitochondria-targeting Cu3VS4 nanostructure with high copper ionic mobility for photothermoelectric therapy

Y Dong, S Dong, C Yu, J Liu, S Gai, Y Xie, Z Zhao… - Science …, 2023 - science.org
Thermoelectric therapy has emerged as a promising treatment strategy for oncology, but it is
still limited by the low thermoelectric catalytic efficiency at human body temperature and the …

[HTML][HTML] Organelle-targeted therapies: a comprehensive review on system design for enabling precision oncology

J Yang, A Griffin, Z Qiang, J Ren - Signal transduction and targeted …, 2022 - nature.com
Cancer is a major threat to human health. Among various treatment methods, precision
therapy has received significant attention since the inception, due to its ability to efficiently …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Dynamic assembly of DNA nanostructures in living cells for mitochondrial interference

F Li, Y Liu, Y Dong, Y Chu, N Song… - Journal of the American …, 2022 - ACS Publications
Constructing artificial dynamic architectures inside cells to rationally interfere with organelles
is emerging as an efficient strategy to regulate the behaviors and fate of cells, thus providing …

Unraveling mitochondria‐targeting reactive oxygen species modulation and their implementations in cancer therapy by nanomaterials

H Peng, F Yao, J Zhao, W Zhang, L Chen, X Wang… - …, 2023 - Wiley Online Library
Functional subcellular organelle mitochondria are emerging as a crucial player and driver of
cancer. For maintaining the sites of cellular respiration, mitochondria experience production …