Thoracic aortic dissection (TAD) is a highly lethal vascular disease. In many patients with
TAD, the aorta progressively dilates and ultimately ruptures. Dissection formation …

Aortic aneurysms are responsible for a significant number of all deaths in Western countries.
In this review we provide a perspective on the important progress made over the past …

Objective Granzyme B (GrB) is a pro-apoptotic serine protease that contributes to immune-
mediated target cell apoptosis. However, during inflammation, GrB accumulates in the …

Granzyme B (GZMB) is a proapoptotic serine protease that is released by cytotoxic
lymphocytes. However, GZMB can also be produced by other cell types and is capable of …

BACKGROUND Extracellular matrix alterations are important elements in the arterial
changes seen in diabetes, being associated with increased vascular stiffness and the …

Snakes of the genus Bothrops are responsible the most snakebites in the Brazil, causing a
diverse and complex pathophysiological condition. Bothrops erythromelas is the main …

Stiffening of the aorta is an important independent risk factor for myocardial infarction and
stroke. Yet its genetics is complex and little is known about its molecular drivers. We have …

Aortic dissection (AD) is a severe vascular disease associated with major morbidity and
mortality. The diagnosis of AD requires the performance of urgent aortic imaging exams …

Fibulins are a group of extracellular matrix proteins of which many are present in high
amounts in the cardiovascular system. They share common biochemical properties and are …

Background Aortic dissection (AD) is an acute process of large blood vessels characterized
by dangerous pathogenic conditions and high disability and high mortality. The …