[HTML][HTML] A novel MIPgene mutation associated with autosomal dominant congenital cataracts in a Chinese family
Y Yu, Y Yu, P Chen, J Li, Y Zhu, Y Zhai, K Yao - BMC Medical Genetics, 2014 - Springer
Background The major intrinsic protein gene (MIP), also known as MIP26 or AQP0, is a
member of the water-transporting aquaporin family, which plays a critical role in the …
member of the water-transporting aquaporin family, which plays a critical role in the …
Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability
K Varadaraj, J Gao, RT Mathias, S Kumari - Experimental Eye Research, 2024 - Elsevier
Clouding of the eye lens or cataract is an age-related anomaly that affects middle-aged
humans. Exploration of the etiology points to a great extent to oxidative stress due to …
humans. Exploration of the etiology points to a great extent to oxidative stress due to …
[HTML][HTML] Expression profiling after retinal detachment and reattachment: a possible role for aquaporin-0
purpose. Retinal detachment (RD) is associated with acute visual loss caused by anatomic
displacement of the photoreceptors and with chronic visual loss/disturbance caused by …
displacement of the photoreceptors and with chronic visual loss/disturbance caused by …
AQP5 deficiency promotes the senescence of lens epithelial cells through mitochondrial dysfunction
K Zhang, G Di, B Li, H Ge, Y Bai, W Bian… - Biochemical and …, 2023 - Elsevier
Cataract is lens opacity, which is a common blinding eye disease worldwide. Aquaporin 5
(AQP5) is expressed in the human and mouse lenses. This study aimed to investigate the …
(AQP5) is expressed in the human and mouse lenses. This study aimed to investigate the …
[HTML][HTML] C-terminal end of Aquaporin 0 regulates lens gap junction channel function
K Varadaraj, J Gao, RT Mathias… - … Ophthalmology & Visual …, 2019 - tvst.arvojournals.org
Purpose: We reported previously that aquaporin 0 (AQP0) modulates lens fiber cell gap
junction (GJ) channel function. The present study was conducted to find out whether the C …
junction (GJ) channel function. The present study was conducted to find out whether the C …
[HTML][HTML] Deletion of seventeen amino acids at the C-terminal end of aquaporin 0 causes distortion aberration and cataract in the lenses of AQP0ΔC/ΔC mice
K Varadaraj, S Kumari - Investigative Ophthalmology & Visual …, 2019 - iovs.arvojournals.org
Purpose: Investigate the effects of the absence of 17 amino acids at the C-terminal end of
Aquaporin 0 (AQP0) on lens transparency, focusing property, and homeostasis. Methods: A …
Aquaporin 0 (AQP0) on lens transparency, focusing property, and homeostasis. Methods: A …
[HTML][HTML] MIP/Aquaporin 0 Represents a Direct Transcriptional Target of PITX3 in the Developing Lens
EA Sorokina, S Muheisen, N Mlodik, EV Semina - PLoS One, 2011 - journals.plos.org
The PITX3 bicoid-type homeodomain transcription factor plays an important role in lens
development in vertebrates. PITX3 deficiency results in a spectrum of phenotypes from …
development in vertebrates. PITX3 deficiency results in a spectrum of phenotypes from …
Differential protein expression in lens epithelial whole-mounts and lens epithelial cell cultures
MD Ong, DM Payne, MH Garner - Experimental eye research, 2003 - Elsevier
Purpose. Lens fibergenesis is a problem in several types of cataract and in the posterior
capsular opacification following cataract surgery. To correct improper fiber differentiation or …
capsular opacification following cataract surgery. To correct improper fiber differentiation or …
[HTML][HTML] Lens major intrinsic protein (MIP)/aquaporin 0 expression in rat lens epithelia explants requires fibroblast growth factor-induced ERK and JNK signaling
N Golestaneh, J Fan, RN Fariss, WK Lo… - Journal of Biological …, 2004 - ASBMB
Lens major intrinsic protein (MIP), exclusive to the vertebrate lens, otherwise known as
MIP26 and Aquaporin 0, is abundantly expressed as a lens fiber membrane protein …
MIP26 and Aquaporin 0, is abundantly expressed as a lens fiber membrane protein …
[HTML][HTML] Age-related cataracts in α3Cx46-knockout mice are dependent on a calpain 3 isoform
Y Tang, X Liu, RK Zoltoski, LA Novak… - … & visual science, 2007 - arvojournals.org
purpose. Previous studies have demonstrated that in 129α3Cx46−/− mice, age-related
nuclear cataract is formed. In the present study, a more in vivo-relevant model was …
nuclear cataract is formed. In the present study, a more in vivo-relevant model was …