The mechanisms regulating the permeability of lens epithelial cell gap junctions in response
to calcium ionophore or ATP agonist-mediated increases in cytosolic Ca2+ (Cai2+) have …

Two classes of channel-forming proteins in the eye lens, the water channel aquaporin-0
(AQP-0) and the connexins Cx46 and Cx50, are preferentially located in different regions of …

Purpose To detect the causative mutation for congenital posterior polar cataracts in a five-
generation Chinese family and further explore the potential pathogenesis of this disease …

To examine the effects of increased expression of Cx50 in the mouse lens, transgenic mice
were generated using a DNA construct containing the human Cx50 coding region and a C …

Methods MIP/AQP0 expression and cellular localization was studied in rat lens epithelia
explants induced to differentiate by FGF-2. MIP wild type (WT) and MIP (S235A) mutant …

Water homeostasis and the structural integrity of the vertebrate lens is partially mediated by
AQP0 channels. Emerging evidence indicates that external pH may be involved in channel …

purpose. Major intrinsic protein (MIP), also called aquaporin-0, is essential for lens
transparency and is specifically expressed in the lens fiber cell membranes. The goal of the …

Calmodulin (CaM) directly interacts with the aquaporin 0 (AQP0) C-terminus in a calcium
dependent manner to regulate the water permeability of AQP0. We previously identified a …

Purpose.: Lim2 (MP20) is the second most abundant integral protein of lens fiber cell
membranes. A comparative analysis was performed of wild-type and Lim2-deficient (Lim2 …

Previous RT-PCR experiments revealed the expression of gene transcripts for a variety of
aquaporins in the neural retina, including aquaporin-0. We investigated by …