Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …

Janus tyrosine kinase (JAK) family of proteins have been identified as crucial proteins in
signal transduction initiated by a wide range of membrane receptors. Among the proteins in …

The concept that the pattern of metastatic spread of cancer is not random and that cancer
cells exhibit preferences when metastasizing to organs, dates back to 1889 when Steven …

The microenvironment of lymph node metastasized tumors (LNMT) determines tumor
progression and response to therapy, but a systematic study of LNMT is lacking. Here, we …

The cancer stem cell (CSC) hypothesis has captured the attention of many scientists. It is
believed that elimination of CSCs could possibly eradicate the whole cancer. CSC surface …

Distant metastasis accounts for the vast majority of deaths in patients with cancer. Breast
cancer exhibits a distinct metastatic pattern commonly involving bone, liver, lung, and brain …

As one of the most serious threats to human being, cancer is hard to be treated when
metastasis happens. What's worse, there are few identified targets of metastasis for drug …

Chemokines are mostly known for their chemotactic properties, and less for their ability to
direct the biological function of target cells, including T cells. The current review focuses on a …

Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …

Abstract Background Glioma initiating cells (GICs), also known as glioma stem cells (GSCs),
play an important role in the progression and recurrence of glioblastoma multiforme (GBM) …