The importance of exosomal PDL1 in tumour immune evasion

D Daassi, KM Mahoney, GJ Freeman - Nature Reviews Immunology, 2020 - nature.com
The interaction of programmed cell death 1 ligand 1 (PDL1) with its receptor programmed
cell death 1 (PD1) inhibits T cell responses, and blockade of this interaction has proven to …

The PD-1/PD-L1 axis and virus infections: a delicate balance

G Schönrich, MJ Raftery - Frontiers in cellular and infection …, 2019 - frontiersin.org
Programmed cell death protein (PD-1) and its ligands play a fundamental role in the evasion
of tumor cells from antitumor immunity. Less well appreciated is the fact that the PD-1/PD-L1 …

Soluble programmed death ligand-1 (sPD-L1): a pool of circulating proteins implicated in health and diseases

C Bailly, X Thuru, B Quesnel - Cancers, 2021 - mdpi.com
Simple Summary The interaction of programmed cell death ligand-1 (PDL1) with its receptor
PD1 inhibits T-cell responses. Blockade of this interaction with monoclonal antibodies leads …

Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential

L Flórez-Álvarez, EE de Souza, VF Botosso… - Frontiers in …, 2022 - frontiersin.org
Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the
emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) …

Species-specific responses during Seoul orthohantavirus infection in human and rat lung microvascular endothelial cells

D Noack, MCGN van den Hout… - PLOS Neglected …, 2024 - journals.plos.org
Seoul orthohantavirus (SEOV) is a rat-borne zoonotic virus that is transmitted via inhalation
of aerosolized infectious excreta, and can cause hemorrhagic fever with renal syndrome …

Viruses run: the evasion mechanisms of the antiviral innate immunity by hantavirus

Y Zhang, R Ma, Y Wang, W Sun, Z Yang… - Frontiers in …, 2021 - frontiersin.org
Hantavirus can cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia and
hantavirus pulmonary syndrome (HPS) in America, with high mortality and unknown …

Mechanisms of PD-L1 regulation in malignant and virus-infected cells

H Farrukh, N El-Sayes, K Mossman - International Journal of Molecular …, 2021 - mdpi.com
Programmed cell death protein 1 (PD-1), a receptor on T cells, and its ligand, PD-L1, have
been a topic of much interest in cancer research. Both tumour and virus-infected cells can …

Comprehensive analysis of CTLA-4 in the tumor immune microenvironment of 33 cancer types

C Zhang, J Chen, Q Song, X Sun, M Xue, Z Yang… - International …, 2020 - Elsevier
Immunotherapy has recently become a powerful weapon against cancer. Cytotoxic T
lymphocyte-associated antigen-4 (CTLA-4) was the first immune checkpoint used for …

Replication in the mononuclear phagocyte system (MPS) as a determinant of hantavirus pathogenicity

MJ Raftery, P Lalwani, N Lütteke, L Kobak… - Frontiers in cellular …, 2020 - frontiersin.org
Members of different virus families including Hantaviridae cause viral hemorrhagic fevers
(VHFs). The decisive determinants of hantavirus-associated pathogenicity are still enigmatic …

Immune Regulation Patterns in Response to Environmental Pollutant Chromate Exposure-Related Genetic Damage: A Cross-Sectional Study Applying Machine …

Z Su, Y Zhang, S Hong, Q Zhang, Z Ji… - Environmental …, 2024 - ACS Publications
Exposure to hexavalent chromium damages genetic materials like DNA and chromosomes,
further elevating cancer risk, yet research rarely focuses on related immunological …