Ebola virus and other orthoebolaviruses cause severe haemorrhagic fevers in humans, with
very high case fatality rates. Their non-segmented single-stranded RNA genome encodes …

This review focuses on the recent progress in our understanding of filovirus protein
structure/function and its impact on antiviral research. Here we focus on the surface …

Emerging viral diseases pose a unique risk to public health, and thus there is a need to
develop therapies. A current focus of funding agencies, and hence research, is the …

Mannose-binding lectin (MBL), a microbe-recognition protein in serum, binds to high
mannose glycans on HIV-1 gp120 and has been reported to neutralize the cell line-adapted …

Carbohydrate–receptor interactions are often involved in the docking of viruses to host cells,
and this docking is a necessary step in the virus life cycle that precedes infection and …

HIV infects macrophages and microglia in the central nervous system (CNS). Mechanisms
that enhance HIV macrophage/microglial tropism are not well understood. Here, we identify …

Abstract Background. The lectin DC-SIGN (dendritic cell-specific intercellular adhesion
molecule 3-grabbing nonintegrin) augments Ebola virus (EBOV) infection. However, it its …

Ebola virus (EBOV) glycoprotein (GP), responsible for mediating host-cell attachment and
membrane fusion, contains a heavily glycosylated mucin-like domain hypothesized to shield …

The structure and function of cells are critically dependent on membranes, which not only
separate the interior of the cell from its environment but also define the internal …

The ongoing evolution of Ebolaviruses poses significant challenges to the development of
immunodiagnostics for detecting emergent viral variants. There is a critical need for the …