The endoplasmic reticulum (ER) is a multifunctional organelle required for lipid biosynthesis,
calcium storage, and protein folding and processing. A number of physiological and …

Tumor necrosis factor (TNF) and its receptors are widely expressed in non-small cell lung
cancer (NSCLC). TNF has an established role in inflammation and also plays a key role in …

The discovery of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR TKI) has
led to unprecedented clinical response in a subset of lung cancer patients carrying the …

[Frontiers in Bioscience 13, 1857-1865, January 1, 2008] 1857 Crosstalk between G-protein-coupled
receptors and Epidermal growt Page 1 [Frontiers in Bioscience 13, 1857-1865, January 1 …

Lung carcinogenesis is a complex process involving the acquisition of genetic mutations that
confer cancer development and the malignant phenotype, and is critically linked to …

Inflammatory processes are essential for innate immunity and contribute to carcinogenesis
in various malignancies, such as colorectal cancer, esophageal cancer and lung cancer …

Celecoxib is an NSAID that was developed as a selective inhibitor of COX-2 and approved
by the FDA for the treatment of various forms of arthritis and the management of acute or …

BACKGROUND Previous studies have shown that COX‐2 inhibitors inhibit cancer cell
proliferation. However, the molecular mechanism remains elusive. METHODS Prostate …

Highlights•COX-2 is overexpressed in tumour cells and is involved in cell proliferation and
progression and angiogenesis.•COX-2 inhibitors can block various signalling pathways …

Over the past decade, a multitude of targeted agents have been explored in the treatment of
advanced non–small cell lung cancer (NSCLC). Thus far, two broad classes of agents have …