The median survival for patients with malignant pleural mesothelioma remains extremely
poor and there is a need for the development of more effective treatment modalities. The …

Age-related macular degeneration (ARMD) is a leading cause of blindness. The major
reason for severe vision loss in ARMD is choroidal neovascularization due to an elevation in …

BACKGROUND: Radiosensitivity by blocking the epidermal growth factor receptor and
cyclooxygenase-2 pathways with erlotinib and celecoxib in A549 human lung cancer cell …

Epidermal growth factor inhibition (EGFR) is emerging as an important treatment modality in
several epithelial malignancies, including head and neck squamous cell carcinoma …

The COX-2 inhibitor Celecoxib, tested in phase III trials for the prevention of sporadic colon
adenomas, reduced the appearance of new adenomas, but was unable to affect the …

G-protein–coupled receptors (GPCR) activate the epidermal growth factor receptor (EGFR)
and mediate EGFR-independent signaling pathways to promote the growth of a variety of …

Objectives To investigate the interaction between tramadol and representative tyrosine
kinase inhibitors, and to study the inhibition mode of drug-interaction. Methods Liver …

BACKGROUND. Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs)
have demonstrated clinical benefit in patients with nonsmall cell lung cancer (NSCLC) …

Previous studies suggest that cyclooxygenase-2 (COX-2) expression may predict survival
among patients with non-small cell lung cancer. COX-2 may interact with epidermal growth …

Hypoxia-inducible factor (HIF) accumulates when tumors grow under hypoxic conditions.
The genesis of tumors, however, usually involves normoxic conditions. In this study, we were …