Targeted therapies reduce growth of mutant epidermal growth factor receptor (EGFR) non-
small cell lung cancers, but most patients develop drug resistance. This has led to efforts to …

The aim of this project was to investigate pharmacological methods of overcoming
resistance in cancer. Novel compounds, targeted therapies and non-steroidal anti …

Cancer metastasis is a multistep process that involves tumor cell migration and invasion
through tumor stroma, intravasation into and extravasation out of the blood vessels, and …

Head and neck squamous cell carcinoma (HNSCC) is characterized by the overexpression
of the epidermal growth factor receptor. However, molecular targeting strategies against …

In 2007 the long-term outcome of lung cancer is still disappointing, with a 5-year survival
rate not exceeding 15%. However, small but significant improvements in survival times have …

Several types of cancer, including bladder cancer, overexpress multiple receptor tyrosine
kinases (RTKs), such as the c-Kit receptor and platelet derived growth factor receptor …

Globally lung cancer results in more deaths than any other cancer, indicating a need for
more and better treatments. One example of a new treatment is Bevacizumab, an …

Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL
TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL …

Progression and metastasis of cancer proceeds in the context of a host response that
includes interactions with immune cells that can both attenuate and paradoxically promote …

Eine zytostatische Chemotherapie liefert bei der Behandlung fortgeschrittener
Tumorerkrankungen oft nur unbefriedigende Ergebnisse. In der Dermatoonkologie stellt …