Synthesis and assembly of fungal melanin

HC Eisenman, A Casadevall - Applied microbiology and biotechnology, 2012 - Springer
Melanin is a unique pigment with myriad functions that is found in all biological kingdoms. It
is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) …

The biosynthetic logic of polyketide diversity

C Hertweck - Angewandte Chemie International Edition, 2009 - Wiley Online Library
Abstract Molecular Lego: Polyketides represent a highly diverse group of natural products
with structurally intriguing carbon skeletons (see picture) which are assembled from simple …

Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans

V Schroeckh, K Scherlach… - Proceedings of the …, 2009 - National Acad Sciences
Fungi produce numerous low molecular weight molecules endowed with a multitude of
biological activities. However, mining the full-genome sequences of fungi indicates that their …

Triggering cryptic natural product biosynthesis in microorganisms

K Scherlach, C Hertweck - Organic & biomolecular chemistry, 2009 - pubs.rsc.org
Natural products from microorganisms are a crucial source for novel therapeutics. Even so, it
seems that many valuable compounds are overlooked when culturing microbes under …

Monascus secondary metabolites: production and biological activity

P Patakova - Journal of Industrial Microbiology and …, 2013 - academic.oup.com
The genus Monascus, comprising nine species, can reproduce either vegetatively with
filaments and conidia or sexually by the formation of ascospores. The most well-known …

Natural products of filamentous fungi: enzymes, genes, and their regulation

D Hoffmeister, NP Keller - Natural product reports, 2007 - pubs.rsc.org
Covering: up to June 2006We review the literature on the enzymes, genes, and whole gene
clusters underlying natural product biosyntheses and their regulation in filamentous fungi …

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

S Bergmann, J Schümann, K Scherlach… - Nature chemical …, 2007 - nature.com
In the postgenomic era it has become increasingly apparent that the vast number of
predicted biosynthesis genes of microorganisms is not reflected by the metabolic profile …

Metabolic engineering for the production of natural products

LB Pickens, Y Tang, YH Chooi - Annual review of chemical and …, 2011 - annualreviews.org
Natural products and their derivatives play an important role in modern healthcare as
frontline treatments for many diseases and as inspiration for chemically synthesized …

The chemistry and biology of cytochalasans

K Scherlach, D Boettger, N Remme… - Natural product reports, 2010 - pubs.rsc.org
The chemistry and biology of cytochalasans - Natural Product Reports (RSC Publishing) DOI:10.1039/B903913A
Royal Society of Chemistry View PDF VersionPrevious ArticleNext Article DOI: 10.1039/B903913A …

Biosynthesis of polyketides by trans-AT polyketide synthases

J Piel - Natural product reports, 2010 - pubs.rsc.org
Covering: up to the end of 2008 This review discusses the biosynthesis of natural products
that are generated by trans-AT polyketide synthases, a family of catalytically versatile …