NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

Ethanol misuse is frequently associated with a multitude of profound medical conditions,
contributing to health-, individual-and social-related damage. A particularly dangerous threat …

MYC as a transcriptional factor plays a crucial role in breast cancer progression. However,
the mechanisms underlying MYC deubiquitination in breast cancer are not well defined …

Abstract TANK-binding kinase 1 (TBK1) responds to microbial stimuli and mediates the
induction of type I interferon (IFN). Here, we show that TBK1 is also a central mediator of …

Intestinal immunity and homeostasis are maintained through the regulation of cytokine
trafficking, microbiota, necrosis and apoptosis. Intestinal immunity and homeostasis …

Dendritic cells (DCs) are indispensable for defense against pathogens but may also
contribute to immunopathology. Activation of DCs upon the sensing of pathogens by Toll-like …

OTU domain-containing ubiquitin aldehyde-binding proteins 1 (OTUB1) is the most
important element of the deubiquitinase OTU superfamily, which has been identified as an …

Background CCN6 is a matricellular protein that critically regulates the tumourigenesis and
progression of breast cancer. Although the tumour‐suppressive function of CCN6 has been …

Post-translational modification of cellular proteins by ubiquitin regulates numerous cellular
processes, including cell division, immune responses, and apoptosis. Ubiquitin-mediated …