Chronic kidney disease (CKD) is a global health problem with rising incidence and
prevalence. Among several pathogenetic mechanisms responsible for disease progression …

Kidney disease is a significant health problem worldwide, affecting an estimated 10% of the
global population. Kidney disease encompasses a diverse group of disorders that vary in …

Indoxyl sulfate is a protein-bound uremic toxin synthesized from indole that cannot be
efficiently removed by the hemodialysis method and thus becomes a key risk factor for the …

Drug nephrotoxicity is a common healthcare problem in hospitalized patients and a major
limitation during drug development. Multi-segmented kidney organoids derived from human …

Global warming further increases the toxic threat of environmental pollutants on organisms.
In order to reveal the dimensions of this threat more clearly, it is of great importance that the …

The pivotal role of the tumor microenvironment (TME) in the initiation and advancement of
hepatocellular carcinoma (HCC) is widely acknowledged, as it fosters the proliferation and …

Chronic kidney disease (CKD) predisposes one toward end-stage renal disease (ESRD)
and its associated morbidity and mortality. Significant metabolic perturbations in conjunction …

Objective: It is very important and controversial when to start treatment in patients with
hyperuricemia (HUA) without gout and chronic kidney disease (CKD). In this study, Raman …

Initial cysts that are formed upon Pkd1 loss in mice impose persistent stress on surrounding
tissue and trigger a cystic snowball effect, in which local aberrant PKD-related signaling …

Systemic lupus erythematosus (SLE) is a severe autoimmune disease with significant
socioeconomic impact worldwide. Orderly energy metabolism is essential for normal …