[HTML][HTML] Correlation between hemolytic activity, cytotoxicity and systemic in vivo toxicity of synthetic antimicrobial peptides

I Greco, N Molchanova, E Holmedal, H Jenssen… - Scientific reports, 2020 - nature.com
The use of non-standard toxicity models is a hurdle in the early development of antimicrobial
peptides towards clinical applications. Herein we report an extensive in vitro and in vivo …

Recent advances in the development of anti-infective peptoids

KL Bicker, SL Cobb - Chemical Communications, 2020 - pubs.rsc.org
In the search for new sources of antimicrobials many researchers have investigated
antimicrobial peptides (AMPs) as templates for the design of innovative therapeutics …

[HTML][HTML] Engineered cationic antimicrobial peptides (eCAPs) to combat multidrug-resistant bacteria

B Deslouches, RC Montelaro, KL Urish, YP Di - Pharmaceutics, 2020 - mdpi.com
The increasing rate of antibiotic resistance constitutes a global health crisis. Antimicrobial
peptides (AMPs) have the property to selectively kill bacteria regardless of resistance to …

[HTML][HTML] Topoisomeric Membrane-Active Peptides: A Review of the Last Two Decades

A Carrera-Aubesart, M Gallo, S Defaus, T Todorovski… - Pharmaceutics, 2023 - mdpi.com
In recent decades, bioactive peptides have been gaining recognition in various biomedical
areas, such as intracellular drug delivery (cell-penetrating peptides, CPPs) or anti-infective …

[HTML][HTML] An Antibacterial Peptide with High Resistance to Trypsin Obtained by Substituting d-Amino Acids for Trypsin Cleavage Sites

X Zhao, M Zhang, I Muhammad, Q Cui, H Zhang, Y Jia… - Antibiotics, 2021 - mdpi.com
The poor stability of antibacterial peptide to protease limits its clinical application. Among
these limitations, trypsin mainly exists in digestive tract, which is an insurmountable obstacle …

Self-assembling, ultrashort peptide gels as antimicrobial biomaterials

M Kurbasic, E Parisi, AM Garcia… - Current Topics in …, 2020 - ingentaconnect.com
Supramolecular antimicrobial hydrogels based on peptides are attractive soft materials for
the treatment of infections, considering their ease of preparation and benign fate in …

Design of improved synthetic antifungal peptides with targeted variations in charge, hydrophobicity and chirality based on a correlation study between biological …

EB Toledo, DR Lucas, TLBV Simão, SD Calixto… - Amino Acids, 2021 - Springer
Microbial resistance to available drugs is a growing health threat imposing the need for the
development of new drugs. The scaffold of plant defensins, including their γ-cores, are …

[HTML][HTML] Structure-Activity Study of an All-d Antimicrobial Octapeptide D2D

A Lone, TT Thomsen, JE Nielsen, PW Thulstrup… - Molecules, 2019 - mdpi.com
The increasing emergence of multi-drug resistant bacteria is a serious threat to public health
worldwide. Antimicrobial peptides have attracted attention as potential antibiotics since they …

[图书][B] Expanding the Toolbox of Structure-Inducing Peptoid Monomers: Synthesis, Conformational Analysis, and Applications of N-Imino, N-Alkylamino, and N-3 …

C Davern - 2023 - search.proquest.com
Peptoids are a class of peptidomimetics in which the side chain is bound to the backbone
nitrogen rather than the α-carbon, giving N-substituted glycine oligomers. Compared to …

Using Fluorescence to Enable Innovative Functions of Foldamers

AA Fuller, JL Moreno Jr… - Israel Journal of Chemistry, 2021 - Wiley Online Library
Monodisperse, sequence‐specific oligomers that adopt regular three‐dimensional
structures, termed foldamers, have found widespread use as biomimetics, sensors, and …