It has been proposed that a loss of bioenergetic capacity of cells contributes to the
progressive loss of biological function with age. Aging is associated with loss of …

Renal disease affects millions of people worldwide, imposing an enormous financial burden
for health-care systems. Recent evidence suggests that mitochondria play an important role …

Mitochondria are essential for eukaryotic cell activity and function, and their dysfunction is
associated with the development and progression of renal diseases. In recent years, there …

Mitochondrial dysfunction is important in the pathogenesis of various kidney diseases and
the mitochondria potentially serve as therapeutic targets necessitating further investigation …

Hypertension remains an important modifiable risk factor for cardiovascular disease,
associated with increased morbidity and mortality. Deciphering the mechanisms involved in …

Mitochondrial injury contributes to renal dysfunction in several models of renal disease, but
its involvement in human hypertension remains unknown. Fragments of the mitochondrial …

Mounting evidence suggests that altered lubricant levels within synovial fluid have acute
biological consequences on chondrocyte homeostasis. While these responses have been …

To test the hypothesis that intrinsic renal scattered tubular cells (STC-like cells) contribute to
repairing injured tubular epithelial cells (TEC) by releasing extracellular vesicle (EV). EV …

Melatonin, due to its multiple means and mechanisms of action, plays a fundamental role in
the regulation of the organismal physiology by fine tunning several functions. The …

Recent studies show that it is now eminently feasible to pharmacologically manipulate
various key aspects of mitochondrial biology in the kidney, and this has much potential for …