Pericytes are considered reparative mesenchymal stem cell-like cells, but their ability to
ameliorate chronic ischemic kidney injury is unknown. We hypothesized that pericytes would …

Background. Coexisting metabolic syndrome (MetS) and renal artery stenosis (RAS) are
linked to poor renal outcomes. Mesenchymal stem/stromal cell‐(MSC‐) derived extracellular …

Aims The mechanisms responsible for cardiac damage in the early stages of metabolic
syndrome (MetS) remain unknown. Mitochondria are intimately associated with cellular …

Clinicians must recognize clinical syndromes that identify 'high-risk'groups and apply
revascularization in those likely to benefit. Future efforts to protect the kidney (eg …

Hypercholesterolemia is a major risk factor for atherosclerosis. Remaining challenges in the
management of atherosclerosis necessitate development of animal models that mimic …

Podocytes are the key target cells for injury across the spectrum of primary and secondary
proteinuric kidney disorders, which account for up to 90% of cases of kidney failure …

Atherosclerotic renal artery stenosis (ARAS) remains a major cause of secondary
hypertension and kidney failure. Randomized prospective trials show that medical treatment …

Objective: Renovascular disease (RVD) produces chronic underperfusion of the renal
parenchyma and progressive ischemic injury. Metabolic abnormalities often accompany …

Methods: Domestic pigs were randomized to control and unilateral ARAS untreated or
treated with subcutaneous elamipretide (5d/wk) for 4 weeks starting after 6 weeks of ARAS …

Aims: REDOX signaling from reactive oxygen species (ROS) generated by the mitochondria
(mitochondrial reactive oxygen species [mtROS]) has been implicated in cancer growth and …