Renal capillary rarefaction is a crucial event that leads to tubulointerstitial damage during
the progression of chronic kidney disease (CKD). In the present study, changes in CD34 …

The mitochondrial-rich renal tubule cells are key regulators of blood homeostasis via
excretion and reabsorption of metabolic waste. With age, tubules are subject to increasing …

Several studies conducted in patients with various stages of chronic kidney disease (CKD)
have investigated the association of iron status markers, such as transferrin saturation …

Background: Dyslipidemia aggravates kidney injury distal to atherosclerotic renal artery
stenosis (ARAS). Besides dyslipidemia, metabolic syndrome (MetS) also involves …

Kidney transplantation is the best therapy for end‐stage renal disease. Demand for kidney
transplantation rises year‐on‐year, and the gap between kidney supply and demand …

Humans produce approximately their body weight equivalent adenosine triphosphate
(ATP)(w65 kg) each day, and although the heart is only w0. 5% of body weight, it consumes …

Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disease caused by
mutations to the dystrophin gene-resulting in deficiency of dystrophin protein, loss of …

Autophagy eliminates excessive nutrients and maintains homeostasis. Obesity and
metabolic syndrome (MetS) dysregulate autophagy, possibly partly due to mitochondria …

Background and Purpose: Elamipretide is a mitochondrial-targeting agent being developed
for the treatment of mitochondrial dysfunction-associated diseases. While prior studies have …

Background Chronic heart failure (HF) remains a rising global epidemic that affects both
adults and children population. The causes of HF are heterogeneous, and syndromes are …