Background With the increasing morbidity and mortality of preeclampsia (PE), it has posed a
huge challenge to public health. Previous studies have reported endoplasmic reticulum (ER) …

The fusion of mononuclear trophoblasts into multinucleate syncytiotrophoblasts is the critical
event in the process of syncytialization, and its dysregulation can lead to pregnancy …

Placental hormones orchestrate maternal metabolic adaptations to support pregnancy. We
hypothesized that placental ER stress, which characterizes early-onset pre-eclampsia (ePE) …

Introduction Preeclampsia is a life-threatening disorder of pregnancy unique to humans.
Interleukin (IL) 11 is elevated in serum from pregnancies that subsequently develop early …

Dysfunction of extravillous trophoblasts (EVTs) might cause early pregnancy failure by
interfering with embryo implantation and/or placentation. We previously reported that the …

Hyperhomocysteinemia may arise from folate/vitamin B12 deficiency, genetic
polymorphisms, kidney disease, or hypothyroidism. It is associated with an increased risk of …

The glycosylphosphatidylinositol (GPI) biosynthetic pathway in the endoplasmic reticulum
(ER) is crucial for generating GPI-anchored proteins (GPI-APs), which are translocated to the …

Advanced maternal age (≥ 35 years) increases the risk of vascular complications in
pregnancy that can result in fetal growth restriction and preeclampsia. Endoplasmic …

The present study aimed to investigate the possible mechanism of action of tumor necrosis
factor-alpha (TNF-a) in endometrial glucose transporter-4 (GLUT-4) expression regulation …

Research question Does the addition of an antioxidant agent, xanthoangelol (XAG), to the
culture medium improve in-vitro development of porcine embryos? Design Early porcine …