Is early-onset cancer an emerging global epidemic? Current evidence and future implications

T Ugai, N Sasamoto, HY Lee, M Ando… - Nature Reviews …, 2022 - nature.com
Over the past several decades, the incidence of early-onset cancers, often defined as
cancers diagnosed in adults< 50 years of age, in the breast, colorectum, endometrium …

Gastric cancer: epidemiology, prevention, classification, and treatment

R Sitarz, M Skierucha, J Mielko… - Cancer management …, 2018 - Taylor & Francis
Gastric cancer is the second most common cause of cancer-related deaths in the world, the
epidemiology of which has changed within last decades. A trend of steady decline in gastric …

Meta-analysis of the relationship between cagA seropositivity and gastric cancer

JQ Huang, GF Zheng, K Sumanac, EJ Irvine, RH Hunt - Gastroenterology, 2003 - Elsevier
Background & Aims: Reports in the literature regarding the relationship of infection with
cagA-positive strains of Helicobacter pylori to gastric cancer over and above H. pylori …

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

H Higashi, R Tsutsumi, A Fujita… - Proceedings of the …, 2002 - National Acad Sciences
Helicobacter pylori is a causative agent of gastritis and peptic ulcer. cagA+ H. pylori strains
are more virulent than cagA− strains and are associated with gastric carcinoma. The cagA …

[HTML][HTML] Helicobacter pylori infection and gastric adenocarcinoma

P Correa, MB Piazuelo - US gastroenterology & hepatology review, 2011 - ncbi.nlm.nih.gov
Gastric adenocarcinoma is the second leading cause of cancer-related mortality worldwide.
Infection with Helicobacter pylori is the strongest recognized risk factor for gastric …

Geographic differences in gastric cancer incidence can be explained by differences between Helicobacter pylori strains

Y Yamaoka, M Kato, M Asaka - Internal medicine, 2008 - jstage.jst.go.jp
Certain populations with high incidences of Helicobacter pylori infection, such as those in
East Asian countries, have high incidences of gastric cancer, while other highly infected …

Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis

M Hatakeyama, H Higashi - Cancer science, 2005 - Wiley Online Library
Infection with cagA‐positive Helicobacter pylori is associated with the development of gastric
adenocarcinoma. The cagA gene product CagA is injected directly from the bacterium into …

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation

H Higashi, A Nakaya, R Tsutsumi, K Yokoyama… - Journal of Biological …, 2004 - ASBMB
The CagA protein of Helicobacter pylori, which is injected from the bacteria into bacteria-
attached gastric epithelial cells, is associated with gastric carcinoma. CagA is tyrosine …

Natural history of Helicobacter pylori infection

P Correa, MB Piazuelo - Digestive and Liver Disease, 2008 - Elsevier
This report describes the modalities of chronic gastritis induced by Helicobacter pylori
infection in different populations. The full gamut of lesions representing the precancerous …

Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA

R Tsutsumi, A Takahashi, T Azuma… - … and cellular biology, 2006 - Am Soc Microbiol
Infection with cagA-positive Helicobacter pylori (H. pylori) is associated with atrophic
gastritis, peptic ulcer, and gastric adenocarcinoma. The cagA gene product CagA is …