Glucosinolates (GSL) are naturally occurring β-d-thioglucosides found across the
cruciferous vegetables. Core structure formation and side-chain modifications lead to the …

Abundant data support a key role for the transcription factor nuclear factor-κB (NF-κB)
signaling pathway in controlling the initiation and progression of human cancer. NF-κB and …

Systematic characterization of cancer genomes has revealed a staggering number of
diverse aberrations that differ among individuals, such that the functional importance and …

Monoclonal antibodies against immune checkpoint blockade have proven to be a major
success in the treatment of melanoma. The programmed death receptor-1 ligand-1 (PD-L1) …

Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to
the mechanisms controlling cellular responses under such stress stimuli, are the …

Background Gene expression profiling has revolutionized our ability to molecularly classify
primary human tumors and significantly enhanced the development of novel tumor markers …

Recently, the rationale for combining targeted therapy with immunotherapy has come to
light, but our understanding of the immune response during MAPK pathway inhibitor …

Radio-and chemotherapy are the most common cancer treatment modalities. They cause
acute and late side effects on normal tissues, which is a burden for delivery of a high dose of …

Melanoma is considered one of the most aggressive skin cancers. It spreads and
metastasizes quickly and is intrinsically resistant to most conventional chemotherapeutics …

Epigallocatechin-3-gallate (EGCG), the major polyphenolic component of green tea, has
been demonstrated to possess anti-inflammatory, antioxidant, anti-mutagenic and anti …