Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, arising from
immature lymphocytes that show uncontrolled proliferation and arrested differentiation …

Simple Summary Janus kinase/signal transducers and activators of transcription (JAK/STAT)
pathway is a crucial cell signaling pathway that drives the development, differentiation, and …

Driver mutations occur in Janus kinase 2 (JAK2), thrombopoietin receptor (MPL), and
calreticulin (CALR) in BCR-ABL1 negative myeloproliferative neoplasms (MPNs). From …

Calreticulin (CALR) frameshift mutations represent the second cause of myeloproliferative
neoplasms (MPN). In healthy cells, CALR transiently and non-specifically interacts with …

Thrombopoietin (TPO) and the TPO-receptor (TPO-R, or c-MPL) are essential for
hematopoietic stem cell (HSC) maintenance and megakaryocyte differentiation. Agents that …

Abstract The family of Janus Kinases (JAKs) associated with the JAK–signal transducers
and activators of transcription signaling pathway plays a vital role in the regulation of various …

The Janus kinases (JAKs) are key components of the JAK-STAT signaling pathway and are
involved in myriad physiological processes. Though they are the molecular targets of many …

Thrombopoietin (Tpo) is the primary regulator of megakaryocyte and platelet numbers and is
required for haematopoetic stem cell maintenance. Tpo functions by binding its receptor …

Detection and conversion of mechanical forces into biochemical signals is known as
mechanotransduction. From cells to tissues, mechanotransduction regulates migration …

Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders with
dysregulated myeloid blood cell production and propensity for transformation to acute …